23‐Oxa‐Analogues of OSW‐1: Efficient Synthesis and Extremely Potent Antitumor Activity

An aldol condensation is the key to the eight-step linear synthesis of 23-oxa analogues of OSW-1 (e.g. 2) in more than 20 % overall yield from the industrially produced steroid 1. Compound 2 is up to 2000 times more potent than cisplatin as an inhibitor of tumor cell growth. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2004/z54237_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.