外胚层
生物
胚芽层
原肠化
内胚层
中胚层
外胚层
细胞生物学
胚胎
胚胎发生中的极性
滋养层
极性(国际关系)
胚泡
节的
解剖
胚胎发生
遗传学
胚胎干细胞
细胞
基因
胎盘
胎儿
怀孕
诱导多能干细胞
作者
Jan Idkowiak,Gunnar Weisheit,Christoph Viebahn
标识
DOI:10.1016/j.semcdb.2004.04.007
摘要
The main aim of the gastrulation process is commonly regarded to be the generation of the definitive germ layers known as mesoderm, endoderm and ectoderm. Here we discuss how the topography of gene expression, cellular migration and proliferative activity in the preliminary germ layers (hypoblast and epiblast) of the rabbit embryo reveal the sequence of events that establishes the three major body axes. We present a testable model in which a combination of cellular movement in the hypoblast with a morphogen gradient created by the (extraembryonic) trophoblast creates morphological polarity in the embryo and, hence, the co-ordinates for germ layer formation.
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