酰胺
分子内力
磺胺
组合化学
化学
尿素
固相合成
立体化学
有机化学
生物化学
肽
作者
Ya Zhou,Aaron B. Beeler,Sang Hyun Cho,Yuehong Wang,Scott G. Franzblau,John K. Snyder
出处
期刊:Journal of combinatorial chemistry
[American Chemical Society]
日期:2008-06-03
卷期号:10 (4): 534-540
被引量:22
摘要
The chemistry of 5,6,7,8-tetrahydro-1,6-naphthyridine scaffolds, synthesized by intramolecular cobalt-catalyzed [2 + 2 + 2] cyclizations, has been exploited for library synthesis. Urea, amide, and sulfonamide formations were used in the synthesis of a 101-membered library. Screening of the library for antituberculosis activity revealed three lead compounds.
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