Anti-Fatigue Activity of Soy Isoflavones in Mice

In the present study, we investigated the anti-fatigue activity in male Kunming mice with Soy isoflavones using a forced swimming test. Mice were divided into four groups (three Soy isoflavones administered groups and a control group). The control group was gavaged with distilled water and Soy isoflavones administered groups were gavaged with Soy isoflavones (10, 20 and 40mg/10g body weight /d). After four weeks, a forced swimming test was performed and the biochemical parameters related to fatigue were examined. The results suggested that Soy isoflavones could extend the swimming time to exhaustion of the mice. This indicated that Soy isoflavones had anti-fatigue activity and could elevate the exercise tolerance.