Influence of Serotonin Transporter Promoter Region Polymorphisms on Hippocampal Volumes in Late-Life Depression

血清素转运体 萧条(经济学) 海马结构 晚年抑郁症 海马体 心理学 5-HTTLPR型 内科学 背景(考古学) 队列 基因型 肿瘤科 医学 内分泌学 血清素 遗传学 生物 基因 宏观经济学 古生物学 经济 受体
作者
Warren D. Taylor,David C. Steffens,Martha E. Payne,James R. MacFall,Douglas A. Marchuk,Ingrid K. Svenson,K. Ranga Rama Krishnan
出处
期刊:Archives of General Psychiatry [American Medical Association]
卷期号:62 (5): 537-537 被引量:174
标识
DOI:10.1001/archpsyc.62.5.537
摘要

Context

Polymorphisms in the promoter region of the serotonin transporter gene (5-HTTLPR) influence transcription and may play a role in the pathogenesis and course of depression. Recent research demonstrates that specific polymorphisms may be associated with differences in hippocampal volumes in subjects with depression.

Objective

To examine associations between5-HTTLPRgenotype and hippocampal volumes in elderly control subjects and elderly subjects classified as having early or late onset of depression.

Design

Cohort study examining baseline characteristics.

Participants

Subjects were community dwelling and 60 years or older. Using a definition of early-onset depression as depression first occurring at 50 years or younger, we examined 72 subjects with early-onset depression, 63 subjects with late-onset depression, and 83 healthy control subjects.

Main Outcome Measures

All subjects underwent genotyping for the5-HTTLPRand underwent brain magnetic resonance imaging. Analyses of hippocampal volumes were controlled for total cerebral volume, age, and sex.

Results

The interaction between diagnosis and5-HTTLPRgenotype was statistically significant for the right hippocampus (P = .04). Subjects with late-onset depression who were homozygous for the long (L) allele (L /L genotype) had significantly smaller right hippocampal volumes than did L /L subjects with early-onset depression (P = .046) or L /L control subjects (P = .01). Post hoc analyses showed that later age of depression onset was associated with smaller hippocampal volumes in subjects with the L /L genotype, but earlier age of onset was associated with smaller hippocampal volumes in subjects who were homozygous for the short (S) allele (S/S genotype).

Conclusions

Subjects with late-onset depression who were homozygous for the L allele exhibited smaller hippocampal volumes than other groups. Genotype also mediated the effect of age of onset on hippocampal volumes. Our findings differ from previous work; however, we examined an older and larger cohort of subjects than previous studies. Possible explanations for these findings include interactions between the serotonergic system and neurotrophic factors or cortisol response to stresses, each of which may affect hippocampal volumes.

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