亲爱的研友该休息了!由于当前在线用户较少,发布求助请尽量完整的填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!身体可是革命的本钱,早点休息,好梦!

Influence of Serotonin Transporter Promoter Region Polymorphisms on Hippocampal Volumes in Late-Life Depression

血清素转运体 萧条(经济学) 海马结构 晚年抑郁症 海马体 心理学 5-HTTLPR型 内科学 背景(考古学) 队列 基因型 肿瘤科 医学 内分泌学 血清素 遗传学 生物 基因 受体 经济 宏观经济学 古生物学
作者
Warren D. Taylor,David C. Steffens,Martha E. Payne,James R. MacFall,Douglas A. Marchuk,Ingrid K. Svenson,K. Ranga Rama Krishnan
出处
期刊:Archives of General Psychiatry [American Medical Association]
卷期号:62 (5): 537-537 被引量:174
标识
DOI:10.1001/archpsyc.62.5.537
摘要

Context

Polymorphisms in the promoter region of the serotonin transporter gene (5-HTTLPR) influence transcription and may play a role in the pathogenesis and course of depression. Recent research demonstrates that specific polymorphisms may be associated with differences in hippocampal volumes in subjects with depression.

Objective

To examine associations between5-HTTLPRgenotype and hippocampal volumes in elderly control subjects and elderly subjects classified as having early or late onset of depression.

Design

Cohort study examining baseline characteristics.

Participants

Subjects were community dwelling and 60 years or older. Using a definition of early-onset depression as depression first occurring at 50 years or younger, we examined 72 subjects with early-onset depression, 63 subjects with late-onset depression, and 83 healthy control subjects.

Main Outcome Measures

All subjects underwent genotyping for the5-HTTLPRand underwent brain magnetic resonance imaging. Analyses of hippocampal volumes were controlled for total cerebral volume, age, and sex.

Results

The interaction between diagnosis and5-HTTLPRgenotype was statistically significant for the right hippocampus (P = .04). Subjects with late-onset depression who were homozygous for the long (L) allele (L /L genotype) had significantly smaller right hippocampal volumes than did L /L subjects with early-onset depression (P = .046) or L /L control subjects (P = .01). Post hoc analyses showed that later age of depression onset was associated with smaller hippocampal volumes in subjects with the L /L genotype, but earlier age of onset was associated with smaller hippocampal volumes in subjects who were homozygous for the short (S) allele (S/S genotype).

Conclusions

Subjects with late-onset depression who were homozygous for the L allele exhibited smaller hippocampal volumes than other groups. Genotype also mediated the effect of age of onset on hippocampal volumes. Our findings differ from previous work; however, we examined an older and larger cohort of subjects than previous studies. Possible explanations for these findings include interactions between the serotonergic system and neurotrophic factors or cortisol response to stresses, each of which may affect hippocampal volumes.

科研通智能强力驱动
Strongly Powered by AbleSci AI
科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
哈兰完成签到 ,获得积分10
4秒前
13秒前
HRZ完成签到 ,获得积分10
19秒前
摘星星发布了新的文献求助10
19秒前
29秒前
苏苏弋发布了新的文献求助10
35秒前
苏苏弋完成签到,获得积分10
40秒前
斯文败类应助老实松鼠采纳,获得10
52秒前
科研通AI5应助吴雨峰采纳,获得30
54秒前
1分钟前
吴雨峰发布了新的文献求助30
1分钟前
善学以致用应助是77呀采纳,获得10
1分钟前
车访枫完成签到 ,获得积分10
1分钟前
1分钟前
1分钟前
1分钟前
1分钟前
打打应助古月采纳,获得10
2分钟前
智慧金刚完成签到 ,获得积分10
2分钟前
2分钟前
domingo发布了新的文献求助10
2分钟前
在水一方应助冷傲的小之采纳,获得10
2分钟前
2分钟前
3分钟前
852应助章鱼采纳,获得10
3分钟前
3分钟前
3分钟前
古月发布了新的文献求助10
3分钟前
Eestern-blot发布了新的文献求助10
3分钟前
烟花应助丨墨月丨采纳,获得10
3分钟前
111完成签到 ,获得积分10
3分钟前
科研通AI2S应助科研通管家采纳,获得10
3分钟前
3分钟前
烟花应助科研通管家采纳,获得10
3分钟前
爱民发布了新的文献求助10
3分钟前
是谁还没睡完成签到 ,获得积分10
3分钟前
3分钟前
令狐井完成签到,获得积分10
3分钟前
丨墨月丨发布了新的文献求助10
4分钟前
棠以秧完成签到 ,获得积分10
4分钟前
高分求助中
The Foraging Behavior of the Honey Bee (Apis mellifera, L.) 1000
Neuromuscular and Electrodiagnostic Medicine Board Review 1000
こんなに痛いのにどうして「なんでもない」と医者にいわれてしまうのでしょうか 510
いちばんやさしい生化学 500
Comprehensive Supramolecular Chemistry II 500
The First Nuclear Era: The Life and Times of a Technological Fixer 500
Avialinguistics:The Study of Language for Aviation Purposes 270
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 物理 生物化学 纳米技术 计算机科学 化学工程 内科学 复合材料 物理化学 电极 遗传学 量子力学 基因 冶金 催化作用
热门帖子
关注 科研通微信公众号,转发送积分 3681624
求助须知:如何正确求助?哪些是违规求助? 3233515
关于积分的说明 9808996
捐赠科研通 2945014
什么是DOI,文献DOI怎么找? 1615024
邀请新用户注册赠送积分活动 762505
科研通“疑难数据库(出版商)”最低求助积分说明 737455