介孔材料
材料科学
介孔二氧化硅
纳米结构
纳米技术
纳米颗粒
蚀刻(微加工)
介孔有机硅
粒子(生态学)
化学工程
化学
有机化学
催化作用
图层(电子)
工程类
地质学
海洋学
作者
Yu Chen,Hangrong Chen,Limin Guo,Qianjun He,Feng Chen,Jian Zhou,Feng Jiang,Jianlin Shi
出处
期刊:ACS Nano
[American Chemical Society]
日期:2009-12-30
卷期号:4 (1): 529-539
被引量:611
摘要
A novel “structural difference-based selective etching” strategy has been developed to fabricate hollow/rattle-type mesoporous nanostructures, which was achieved by making use of the structural differences, rather than traditional compositional differences, between the core and the shell of a silica core/mesoporous silica shell structure to create hollow interiors. Highly dispersed hollow mesoporous silica spheres with controllable particle/pore sizes could be synthesized by this method, which show high loading capacity (1222 mg/g) for anticancer drug (doxorubicin). Hemolyticity and cytotoxicity assays of hollow mesoporous silica spheres were conducted, and the synthesized hollow mesoporous silica spheres with large pores show ultrafast immobilization of protein-based biomolecules (hemoglobin). On the basis of this strategy, different kinds of heterogeneous rattle-type nanostructures with inorganic nanocrystals, such as Au, Fe2O3, and Fe3O4 nanoparticles, as the core and mesoporous silica as the shell were also prepared. This strategy could be extended as a general approach to synthesize various hollow/rattle-type nanostructures by creating adequate structural differences between cores and shells in core/shell structures in nanoscale.
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