医学
硫唑嘌呤
外科
深静脉
并发症
血栓性静脉炎
抗凝血酶
血栓形成
胃肠病学
纤维蛋白原
肾
肾静脉血栓形成
肾移植
内科学
肝素
疾病
作者
Yves Vanrenterghem,L Roels,T. Lerut,Gruwez Ja,Paul Michielsen,Paolo Gresele,Hans Deckmyn,Mario Colucci,Jozef Arnout,Jos Vermylen
出处
期刊:The Lancet
[Elsevier]
日期:1985-05-01
卷期号:325 (8436): 999-1002
被引量:207
标识
DOI:10.1016/s0140-6736(85)91610-1
摘要
The incidence of thromboembolic complications was compared retrospectively in 90 cadaveric kidney allograft recipients treated with cyclosporin and low-dose steroids and the same number of cadaveric kidney allograft recipients treated with azathioprine, antilymphocyte globulin, and high-dose steroids. In the cyclosporin group, 17 thromboembolic complications occurred in 13 patients: 10 pulmonary emboli, 1 renal vein thrombosis, 3 deep vein thromboses, and 3 haemorrhoidal thromboses. In the azathioprine group, the only thromboembolic complication was 1 episode of superficial thrombophlebitis. Haemostatic tests in cyclosporin-treated and azathioprine-treated patients and normal subjects (10 in each group) showed increased concentrations of factor VIII C, fibrinogen, antithrombin III, and protein C in the cyclosporin-treated patients. Adenosine-5'-diphosphate-induced platelet aggregation was also significantly enhanced in the cyclosporin group. The effect of cyclosporin on haemostasis may predispose to thromboembolic complications.
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