血管生成
内生
新生血管
癌症研究
生物
细胞生物学
免疫学
生物化学
出处
期刊:Endothelium (CD-ROM)
[Informa]
日期:2006-01-01
卷期号:13 (2): 147-155
被引量:41
标识
DOI:10.1080/1062332060069110
摘要
Angiogenesis is regulated by a local balance between the levels of endogenous stimulators and inhibitors of angiogenesis. Understanding of the mechanism of angiogenesis has advanced significantly since the discovery of two members of the family of angiogenesis stimulators, i.e., vascular endothelial growth factor family proteins and angiopoietins. These factors act on endothelial cells to stimulate angiogenesis. In contrast, most of angiogenesis inhibitors do not seem to have such characteristics. Very few genes encoding molecules that selectively inhibit angiogenesis have been discovered. This review will focus on our current understanding of endogenous inhibitors of angiogenesis.
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