硫醚
糖复合物
二硫键
糖蛋白
化学
糖基化
聚糖
磷化氢
生物结合
生物化学
组合化学
立体化学
催化作用
作者
Gonçalo J. L. Bernardes,Elizabeth J. Grayson,Sam Thompson,Justin M. Chalker,James C. Errey,Farid El Oualid,Timothy D. W. Claridge,Benjamin G. Davis
标识
DOI:10.1002/anie.200704381
摘要
Strengthening the bond: The introduction of a thiol tag in combination with chemoselective ligation to form a disulfide-linked bioconjugate is a selective and useful method for site-selective protein glycosylation. The phosphine-mediated desulfurization of such glycoconjugates to their reductant-resistant thioether-linked counterparts completes a convergent, site-selective synthesis of thioether-linked glycoproteins (see scheme). Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2008/z704381_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
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