巨噬细胞
香烟烟雾
弹性蛋白酶
肺
肺泡巨噬细胞
烟雾
吸入烟雾
吸入
免疫学
医学
病理
化学
内科学
体外
酶
麻醉
生物化学
有机化学
环境卫生
作者
R. Dean Hautamaki,Dale K. Kobayashi,Robert M. Senior,Steven D. Shapiro
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:1997-09-26
卷期号:277 (5334): 2002-2004
被引量:1386
标识
DOI:10.1126/science.277.5334.2002
摘要
To determine which proteinases are responsible for the lung destruction characteristic of pulmonary emphysema, macrophage elastase–deficient (MME −/− ) mice were subjected to cigarette smoke. In contrast to wild-type mice, MME − / − mice did not have increased numbers of macrophages in their lungs and did not develop emphysema in response to long-term exposure to cigarette smoke. Smoke-exposed MME − / − mice that received monthly intratracheal instillations of monocyte chemoattractant protein–1 showed accumulation of alveolar macrophages but did not develop air space enlargement. Thus, macrophage elastase is probably sufficient for the development of emphysema that results from chronic inhalation of cigarette smoke.
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