硬脑膜
脑-机接口
神经假体
生物医学工程
神经调节
脊髓
脑植入物
材料科学
神经工程
刺激
神经科学
医学
解剖
脑电图
心理学
作者
Ivan R. Minev,Pavel Musienko,Arthur Hirsch,Quentin Barraud,Nikolaus Wenger,Eduardo Martin Moraud,Jérôme Gandar,Marco Capogrosso,Tomislav Milekovic,Léonie Asboth,Rafael Fajardo Torres,Nicolas Vachicouras,Qihan Liu,Н. В. Павлова,Simone Duis,Alexandre Larmagnac,János Vörös,Silvestro Micera,Zhigang Suo,Grégoire Courtine,Stéphanie Lacour
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:2015-01-09
卷期号:347 (6218): 159-163
被引量:832
标识
DOI:10.1126/science.1260318
摘要
The mechanical mismatch between soft neural tissues and stiff neural implants hinders the long-term performance of implantable neuroprostheses. Here, we designed and fabricated soft neural implants with the shape and elasticity of dura mater, the protective membrane of the brain and spinal cord. The electronic dura mater, which we call e-dura, embeds interconnects, electrodes, and chemotrodes that sustain millions of mechanical stretch cycles, electrical stimulation pulses, and chemical injections. These integrated modalities enable multiple neuroprosthetic applications. The soft implants extracted cortical states in freely behaving animals for brain-machine interface and delivered electrochemical spinal neuromodulation that restored locomotion after paralyzing spinal cord injury.
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