The traditional method of the offshore caisson positioning and installing is using the barge or floating crane, but for the large caisson with 26,000 tons, the method is unable to achieve apparently. In this paper, the offshore location and installation of the large caisson with mooring line system and anchor cable system are studied. The research gets the wave and flow conditions results as well as the related and advertent items, which provide the reference for large caisson positioning and installation as well as the similar engineering construction technology.