病毒性心肌炎
心肌炎
炎症
医学
病毒感染
免疫学
心力衰竭
炎症反应
病毒
生物信息学
生物
心脏病学
作者
Maarten F. Corsten,Blanche Schroen,Stéphane Heymans
标识
DOI:10.1016/j.molmed.2012.05.005
摘要
Viral myocarditis is an important cause of heart failure for which no specific treatments are available. Direct viral injury to cardiac cells provokes an inflammatory response that significantly contributes to cardiac damage and ensuing morbidity. Despite the central pathogenic role of autoimmune injury, broad inhibition of the inflammatory response does not result in patient benefit. Many preclinical studies collectively emphasize that modulating distinct inflammatory signaling pathways may yield effective viral clearance while preserving cardiac structure. This review aims to provide an overview of the sometimes contrasting observations from experimental viral myocarditis models and to translate the lessons learned into opportunities for future investigations and therapies.
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