Linkage and haplotype analysis for chemokine receptors clustered on chromosome 3p21.3 and transmitted in family pedigrees with asthma and atopy

A sthma is a complex disease which in childhood is frequently, but not invariably, associated with atopy, 1 and which is only associated with approximately half of all adult cases. 2 Although is likely that many candidate genes contribute to disease expression in view of asthma' s high population prevalence, candidate polymorphisms are also likely to have high population frequencies and play relevant roles in biologically plausible mechanistic pathways.The chemokine pathway is among the many plausible pathways involved in the underlying inflammatory airway responses that are typical of asthma.Linkage and haplotype analysis for chemokine receptors clustered on chromosome 3p21.3and transmitted in family pedigrees with asthma and atopy