神经保护
坏死性下垂
医学
视网膜
程序性细胞死亡
自噬
神经科学
视网膜
细胞凋亡
炎症
细胞生物学
免疫学
药理学
生物
眼科
生物化学
作者
Nicholas D. Chinskey,Cagri G. Besirli,David N. Zacks
出处
期刊:Current Opinion in Ophthalmology
[Ovid Technologies (Wolters Kluwer)]
日期:2014-05-01
卷期号:25 (3): 228-233
被引量:55
标识
DOI:10.1097/icu.0000000000000043
摘要
Purpose of review Retinal cell death is the main cause of vision loss in many blinding conditions. Research on the basics of how and why retinal cells die in different diseases provides insights into the development of treatment strategies to prevent or reverse this loss. This review summarizes the literature published on this topic in the last year. Recent findings Apoptosis is generally considered the main pathway by which retinal cells die in response to a range of noxious stimuli. However, inhibiting apoptosis does not completely prevent retinal cell death, as many enter programmed necrosis or necroptosis. Many novel ways of inhibiting apoptosis and necrosis, including blockage of the Fas receptor, neuroprotective peptides and antioxidants, continue to be investigated. Also, additional pathways including autophagy and inflammation are being examined on how they contribute to the loss of retinal cells in different disease models. Summary With more knowledge of how retinal cells die, further advances are being made in prolonging the cell survival. However, even as basic science discoveries remain promising, clinical utility of neuroprotection is still quite limited at this time.
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