基质金属蛋白酶
细胞外基质
劈开
明胶酶类
细胞生物学
细胞外
底物特异性
酶
病态的
基质(化学分析)
化学
生物
生物化学
医学
病理
明胶酶
色谱法
作者
Henning Birkedal‐Hansen,William G. I. Moore,Malena Bodden,L. Jack Windsor,B Birkedal-Hansen,Arthur A. DeCarlo,Jeffrey A. Engler
出处
期刊:Critical Reviews in Oral Biology & Medicine
[SAGE]
日期:1993-01-01
卷期号:4 (2): 197-250
被引量:2796
标识
DOI:10.1177/10454411930040020401
摘要
Matrix metalloproteinases (MMPs) are a family of nine or more highly homologous Zn ++ endopeptidases that collectively cleave most if not all of the constituents of the extracellular matrix. The present review discusses in detail the primary structures and the overlapping yet distinct substrate specificities of MMPs as well as the mode of activation of the unique MMP precursors. The regulation of MMP activity at the transcriptional level and at the extracellular level (precursor activation, inhibition of activated, mature enzymes) is also discussed. A final segment of the review details the current knowledge of the involvement of MMP in specific developmental or pathological conditions, including human periodontal diseases.
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