蛋白质组
生物化学
生物
铜缺乏
代谢途径
缺铁
铜
新陈代谢
化学
细胞生物学
贫血
医学
内科学
有机化学
作者
Alessandra Tosco,Rosa Anna Siciliano,Giuseppina Cacace,Maria Fiorella Mazzeo,Roberta Capone,Antonio Malorni,Arturo Leone,Liberato Marzullo
摘要
Copper and iron are cofactors of many metallo-proteins that accomplish vital functions, such as oxygen and electron transport. Specific metabolic pathways have been selected through evolution, although still not fully elucidated, to confine the dangerous reactivity of their free ionic forms. Inadequate supply of both metals can severely affect basic physiological functions. A differential analysis of the rat intestinal proteome evidenced the following dietary copper- and iron-deficiencies, i.e., significant changes in the levels of proteins belonging to different functional classes (glucose and fatty acid metabolism, molecular chaperones, cytoskeleton plasticity, vitamin transporters). The presented results bring new perspectives to understand the role of copper and iron in the metabolic pathways and provide novel diagnostic tools to characterize the effects of subclinical deficiencies of both metals in unbalanced nutritional disorders.
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