自身抗体
抗体
硬皮病(真菌)
免疫学
表位
拓扑异构酶
抗原
自身免疫性疾病
医学
免疫系统
可提取核抗原
自身免疫
疾病
抗核抗体
生物
病理
DNA
接种
遗传学
作者
Tamás Czömpöly,Diána Simon,László Czirják,Pèter Németh
标识
DOI:10.1016/j.autrev.2009.02.018
摘要
Systemic sclerosis (SSc) is an autoimmune disease characterized by fibrosis of the skin, vascular abnormalities and activation of the immune system. The majority of SSc patients have autoantibodies against nuclear antigens. Among these antibodies against topoisomerase I (topo I) are frequently detected in sera of SSc patients. Since the discovery of these antibodies as immunoglobulins reacting with a 70 kDa nuclear protein (Scl-70), a massive body of clinical and experimental data has been generated. In this review we summarize accumulated evidence about anti-topo I autoantibodies in SSc, including results of epitope mapping studies and investigations on the possible pathogenic role of these antibodies.
科研通智能强力驱动
Strongly Powered by AbleSci AI