获得性免疫系统
先天免疫系统
免疫
免疫系统
免疫学
疾病
炎症性肠病
炎症
生物
医学
计算生物学
病理
作者
Britta Siegmund,Martin Zeitz
出处
期刊:PubMed
日期:2011-07-21
被引量:22
标识
DOI:10.3748/wjg.v17.i27.3178
摘要
Inflammatory bowel diseases are the consequence of a dysregulated mucosal immune system. The mucosal immune system consists of two arms, innate and adaptive immunity, that have been studied separately for a long time. Functional studies from in vivo models of intestinal inflammation as well as results from genome-wide association studies strongly suggest a cross-regulation of both arms. The present review will illustrate this interaction by selecting examples from innate immunity and adaptive immunity, and their direct impact on each other. Broadening our view by focusing on the cross-regulated areas of the mucosal immune system will not only facilitate our understanding of disease, but furthermore will allow identification of future therapeutic targets.
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