佐剂
免疫系统
免疫
脾细胞
流感疫苗
免疫学
子类
疫苗佐剂
生物
接种疫苗
抗体
作者
Bernt Hjertner,Theresa Bengtsson,Brør Morein,Staffan Paulie,Caroline Fossum
出处
期刊:Vaccine
[Elsevier]
日期:2018-05-01
卷期号:36 (23): 3340-3344
被引量:19
标识
DOI:10.1016/j.vaccine.2018.04.054
摘要
A preferred adjuvant should promote both Th1 and Th2 responses. However, most adjuvants in common use are biased towards a Th2-driven response. Therefore, the ability of a novel saponin-based adjuvant G3 to inducing balanced Th1 and Th2 responses in BALB/c mice immunized with a split trivalent seasonal influenza vaccine was evaluated in comparison to that of the adjuvant Al(OH)3. Clear differences in the IgG profiles induced by G3, Al(OH)3 or non-adjuvanted vaccine were recorded. Both adjuvants enhanced high and similar levels of the Th2 associated IgG1 subtype compared to mice given vaccine alone. Only G3 enhanced the IgG2a subclass reflecting a Th1 response, whereas Al(OH)3 even abrogated the IgG2a production. Accordingly, G3 enhanced the production of IL-2 and IFN-γ and also of IL-2/IFN-γ double secreting cells, emphasizing the strong Th1 driving effect of G3. Only Al(OH)3 increased splenocyte production of IL-17. Taken together, the results indicate a strong propensity for G3 to induce both Th1 and Th2 driven immune responses.
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