纳米片
生存素
光热治疗
基因沉默
小干扰RNA
遗传增强
黑磷
RNA干扰
输送系统
基因传递
核糖核酸
化学
基因
材料科学
癌症研究
纳米技术
生物
医学
生物化学
生物医学工程
光电子学
作者
Huimeng Wang,Lin Zhang,Yang Liu,Xin Xu,Chao Xing,Min Wang,Shumeng Bai,Chunhua Lü,Huanghao Yang
摘要
Gene therapy with small interfering RNA (siRNA) has been proved to be a promising technology to treat various diseases by hampering the production of target proteins. However, developing a delivery system that has high efficiency in transporting siRNA without obvious side effects remains a challenge. Herein, we designed a new survivin siRNA delivery system based on polyethyleneimine functionalized black phosphorus (BP) nanosheets which could suppress tumor growth by silencing survivin expression. Combined with the photothermal properties of the BP nanosheets, the presented delivery system shows excellent therapy efficiency for tumors. Therefore, the BP-based delivery system would be a promising tool for future clinical applications.
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