A Catalyzed Aerobic Intramolecular C–O Bond Formation: Facile Access to Ring-Fused Dihydrobenzoxazine Derivatives

A catalyst comprising of catalytic cobalt(II) acetate/copper(II) acetate/dl-tyrosine with oxygen as the oxidant allows aerobic intramolecular C–O bond construction in [2-(pyrrolidin-1-yl)phenyl]methanol by free-radical promoted intramolecular selective functionalization of an (sp3)C–H bond by the alcohol, thus providing an environmentally friendly approach to 5H-benzo[d]pyrrolo[2,1-b][1,3]oxazine derivatives.