Animal Models of Uveal Melanoma for Localized Interventions

Uveal melanoma is the most common primary intraocular malignancy in adults, carrying a significant risk for death from metastatic disease. Treatment efforts aim toward local tumor control and early detection and management of metastases. Animal models are a valuable tool in the study of the molecular, genetic, and cellular events associated with the development of uveal melanoma and the evaluation of the therapeutic potential for various treatment methods. So far, several spontaneous, transgenetic, or induced animal models have been used, each presenting distinct advantages and disadvantages. This review article systematically presents an analysis of these animal models aimed at localized interventions; We aim to assist researchers with the selection of the optimal animal model based on their particular research targets.