Review question / Objective: Systematically evaluate the effect of brain-computer interface(BCI) training on the rehabilitation of stroke patients.Condition being studied: At present, stroke is one of the main causes of disability in adults, with a disability rate as high as 60% -80%, bringing a heavy economic burden to the country and many families.Therefore, more effective stroke rehabilitation strategies are needed.With the development of rehabilitation medicine technology and artificial intelligence technology, brain-computer interface (BCI) and other technologies that directly intervene the central nervous system have been continuously studied and applied in clinical treatment to help patients recover their mobility and support motor function recovery after stroke.Numerous RCTs have investigated the effects of BCI training on motor and brain function recovery in post-stroke patients, and although these studies have shown significant effects on recovery, the pitfalls of the studies are the small number of participants, the small number of training sessions, and/or the lack of follow-up assessments.The overall goal of this study is to summarize the evidence from RCTs comparing brain-computer interfaces with other treatments in post-stroke patients, focusing on motor function.INPLASY registration number: This protocol was registered with the International Platform of Registered Systematic Review and Meta-Analysis Protocols (INPLASY) on 21 July 2021 and was last u p d a t e d o n 2 1 J u l y 2 0 2 1 ( r e g i s t r a t i o n n u m b e r INPLASY202170067).