小RNA
生物
肾脏发育
肾
形态发生
生物发生
肾脏疾病
基因表达调控
生物信息学
发病机制
计算生物学
基因
遗传学
免疫学
内分泌学
胚胎干细胞
作者
Débora M. Cerqueira,Maliha Tayeb,Jacqueline Ho
出处
期刊:JCI insight
[American Society for Clinical Investigation]
日期:2022-05-09
卷期号:7 (9)
被引量:17
标识
DOI:10.1172/jci.insight.158277
摘要
MicroRNAs (miRNAs) belong to a class of endogenous small noncoding RNAs that regulate gene expression at the posttranscriptional level, through both translational repression and mRNA destabilization. They are key regulators of kidney morphogenesis, modulating diverse biological processes in different renal cell lineages. Dysregulation of miRNA expression disrupts early kidney development and has been implicated in the pathogenesis of developmental kidney diseases. In this Review, we summarize current knowledge of miRNA biogenesis and function and discuss in detail the role of miRNAs in kidney morphogenesis and developmental kidney diseases, including congenital anomalies of the kidney and urinary tract and Wilms tumor. We conclude by discussing the utility of miRNAs as potentially novel biomarkers and therapeutic agents.
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