Strong Out-of-Plane Vibrations and Ultrasensitive Detection of Dopamine-like Neurotransmitters

The detection of monoamine neurotransmitters has become a vital research subject due to their high correlations with nervous system diseases, but insufficient detection precisions have obstructed diagnosis of some related diseases. Here, we focus on four monoamine neurotransmitters, dopamine, norepinephrine, epinephrine, and serotonin, to conduct their rapid and ultrasensitive detection. We find that the low-frequency (<200 cm-1) Raman vibrations of these molecules show some sharp peaks, and their intensities are significantly stronger than those of the high-frequency side. Theoretical calculations identify these peaks to be from strong out-of-plane vibrations of the C-C single bonds at the joint point of the ring-like molecule and its side chain. Using our surface enhanced low-frequency Raman scattering substrates, we show that the detection limit of dopamine as an example can reach 10 nM in artificial cerebrospinal fluid. This work provides a useful way for ultrasensitive and rapid detection of some neurotransmitters.