肌萎缩侧索硬化
神经反射
脑-机接口
计算机科学
神经科学
听觉反馈
听觉皮层
运动皮层
接口(物质)
心理学
医学
脑电图
气泡
并行计算
疾病
病理
刺激
最大气泡压力法
作者
Ujwal Chaudhary,Ioannis Vlachos,Jonas B. Zimmermann,Arnau Espinosa,Alessandro Tonin,Andres Jaramillo-Gonzalez,Majid Khalili-Ardali,Helge Topka,Jens Lehmberg,Gerhard Friehs,A. Woodtli,John P. Donoghue,Niels Birbaumer
标识
DOI:10.1038/s41467-022-28859-8
摘要
Patients with amyotrophic lateral sclerosis (ALS) can lose all muscle-based routes of communication as motor neuron degeneration progresses, and ultimately, they may be left without any means of communication. While others have evaluated communication in people with remaining muscle control, to the best of our knowledge, it is not known whether neural-based communication remains possible in a completely locked-in state. Here, we implanted two 64 microelectrode arrays in the supplementary and primary motor cortex of a patient in a completely locked-in state with ALS. The patient modulated neural firing rates based on auditory feedback and he used this strategy to select letters one at a time to form words and phrases to communicate his needs and experiences. This case study provides evidence that brain-based volitional communication is possible even in a completely locked-in state.
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