»: There are limited data that directly compare the efficacy of antiseptic irrigation solutions used for the prevention and treatment of periprosthetic joint infections in orthopaedic procedures; there is a notable lack of prospective data. »: For prevention of periprosthetic joint infections, the strongest evidence supports the use of low-pressure povidone-iodine. »: For the treatment of periprosthetic joint infections, delivering multiple solutions sequentially may be beneficial.