自愈水凝胶
生物相容性
伤口愈合
透明质酸
壳聚糖
化学
辣根过氧化物酶
过氧化氢
血管生成
皮肤修复
生物医学工程
材料科学
高分子化学
外科
医学
生物化学
有机化学
癌症研究
酶
解剖
作者
Longlong Cui,Jiankang Li,Shuaimeng Guan,Kaixiang Zhang,Kun Zhang,Jingan Li
标识
DOI:10.1016/j.mtbio.2022.100257
摘要
Injectable Hydrogels with adhesive, antioxidant and hemostatic properties are highly desired for promoting skin injury repair. In this study, we prepared a multi-functional carboxymethyl chitosan/hyaluronic acid-dopamine (CMC/HA-DA) hydrogel, which can be crosslinked by horseradish peroxidase and hydrogen peroxide. The antioxidation, gelation time, degradability, rheology and antihemorrhagic properties of hydrogels can be finely tuned by varying composition ratio. The cytocompatibility test and hemolysis test confirmed that the designed hydrogel holds good biocompatibility. More importantly, the repair effect of the hydrogel on full-thickness skin injury model in mice was studied. The results of wound healing, collagen deposition, immunohistochemistry and immunofluorescence showed that CMC/HA-DA hydrogel could significantly promote angiogenesis and cell proliferation at the injured site. Notably, the inflammatory response can also be regulated to promote the repair of full-thickness skin defect in mice. Results indicate that this injectable CMC/HA-DA hydrogel holds high application prospect for promising wound healing.
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