心理压抑
彪马
抄写(语言学)
信号转导
转录因子
细胞生物学
化学
CREB1号
第二信使系统
奶油
基因
生物
基因表达
生物化学
语言学
哲学
作者
Alexander J. Lakhter,Samisubbu R. Naidu
出处
期刊:Melanoma Research
[Ovid Technologies (Wolters Kluwer)]
日期:2017-10-01
卷期号:27 (5): 411-416
被引量:3
标识
DOI:10.1097/cmr.0000000000000363
摘要
The universal second messenger cAMP regulates numerous cellular processes. Although the cAMP-signaling pathway leads to induction of gene transcription, it remains unknown whether this pathway contributes toward suppression of transcription. Here, we show that blockade of cAMP signaling using MDL12330A led to an increase in PUMA transcript levels, but not p21 in melanoma cells. cAMP downstream component Epac activation was essential for suppression of PUMA transcription as an Epac agonist reversed the effects of MDL12330A. These results suggest that transcriptional repression is one of the functions of the cAMP-Epac signaling pathway.
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