Human infections with recently-emerging highly pathogenic H7N9 avian influenza virus in China

Recent articles in this Journal have highlighted the potential for human infections with low pathogenic H7N9 avian influenza virus (LPAIV) via exposure at live poultry markets, 1 Zhou X. Li Y. Wang Y. Edwards J. Guo F. Clements A.C. et al. The role of live poultry movement and live bird market biosecurity in the epidemiology of influenza A (H7N9): a cross-sectional observational study in four eastern China provinces. J Infect. 2015 Oct; 71 ([Observational Study]): 470-479 Abstract Full Text Full Text PDF PubMed Scopus (60) Google Scholar , 2 Wu J. Lau E.H. Xing Q. Zou L. Zhang H. Yen H.L. et al. Seasonality of avian influenza A(H7N9) activity and risk of human A(H7N9) infections from live poultry markets. J Infect. 2015 Dec; 71 ([Letter Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't]): 690-693 Abstract Full Text Full Text PDF PubMed Scopus (15) Google Scholar resulting in severe respiratory disease with a case fatality rate (CFR) of ∼30%. 3 WHO.int Influenza at the human-animal interface – summary and assessment, 17 January to 14 February 2017. 2017http://www.who.int/influenza/human_animal_interface/Influenza_Summary_IRA_HA_interface_02_14_2017.pdf?ua=1 Google Scholar As of March 2017, over 400 cases have been reported in the fifth infection wave with a CFR of ∼40%. Here, we summarize the clinical, laboratory, and genetic results of two patients with viral pneumonia after infection with a novel, highly pathogenic H7N9 avian influenza virus (HPAIV). The role of live poultry movement and live bird market biosecurity in the epidemiology of influenza A (H7N9): A cross-sectional observational study in four eastern China provincesJournal of InfectionVol. 71Issue 4PreviewA new reassortant influenza A (H7N9) virus emerged early 2013 in eastern China. Exposure to H7N9 infected poultry at live bird markets (LBM) was implicated as the main risk factor for human infection. We aimed to identify the role of LBM biosecurity indicators and poultry movement in the affected areas. Full-Text PDF Open Access