溶解
过饱和度
肺表面活性物质
白藜芦醇
化学
多酚
有机化学
生物化学
抗氧化剂
作者
Hongyan He,Qi Zhang,Meiqi Li,Jian‐Rong Wang,Xuefeng Mei
标识
DOI:10.1021/acs.cgd.7b00637
摘要
Resveratrol (RSV), a dietary polyphenol found in red wine, has renewed interest in recent years due to a broad range of in vitro evidence that indicate cardioprotective effects. Herein, we have synthesized four RSV cocrystals with the objective to improve the physicochemical and mechanical properties. Single crystal structures were illustrated and comprehensive characterization of the cocrystals were performed. In addition, powder dissolution of RSV cocrystals in different buffer medium containing different surfactants were conducted, and the result revealed that PVP K30 is an effective surfactant to maintain the supersaturation. Then pharmacokinetic experiments suggested that RSV cocrystals showed shorter Tmax, and RSV–NA exhibited higher Cmax and AUC0–24 values. Furthermore, RSV cocrystals exhibited superior mechanical properties compared to RSV pure component. These results may provide an alternative formulation for RSV.
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