长非编码RNA
癌症研究
癌变
肺癌
细胞生长
基因敲除
生物
癌症
细胞
细胞周期
小RNA
医学
下调和上调
肿瘤科
内科学
细胞培养
基因
遗传学
作者
Yanchun Sun,Shidai Jin,Quan Zhu,Liang Han,Jing Feng,Xiyi Lu,Wei Wang,Feng Wang,Renhua Guo
出处
期刊:Oncotarget
[Impact Journals, LLC]
日期:2017-03-09
卷期号:8 (17): 28297-28311
被引量:76
标识
DOI:10.18632/oncotarget.16044
摘要
Recently, long non-coding RNAs (lncRNAs) have been recognized as playing key roles in regulating cellular processes, such as proliferation, invasion, and metastasis. These lncRNAs have been shown to be abnormally expressed in tumorigenic processes. However, the role and clinical relevance of LUCAT1 in non-small-cell lung cancer (NSCLC) remain unclear. In this study, we found that the expression of LUCAT1 was significantly up-regulated in NSCLC tissues compared to non-tumor tissues, and its expression was associated with tumor size, tumor-node-metastasis (TNM) stage and overall survival (OS). Further experiments showed that LUCAT1 knockdown inhibited cell proliferation both in vitro and in vivo. Mechanistic investigations showed that LUCAT1 plays a key role in G0/G1 arrest. We further demonstrated that LUCAT1 was associated with polycomb repressor complexes (PRC2) and that this association was required for epigenetically repression of p21 and p57, thus contributing to the regulation of NSCLC cell cycle and proliferation. In summary, our results show that LUCAT1 could regulate tumorigenesis of NSCLC and be biomarker for poor prognosis in NSCLC.
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