医学
粘液纤毛清除率
药品
呼吸道
肺
气溶胶化
药物输送
药理学
重症监护医学
呼吸系统
吸入
内科学
麻醉
有机化学
化学
作者
N. R. Labiris,Myrna Dolovich
标识
DOI:10.1046/j.1365-2125.2003.01892.x
摘要
As the end organ for the treatment of local diseases or as the route of administration for systemic therapies, the lung is a very attractive target for drug delivery. It provides direct access to disease in the treatment of respiratory diseases, while providing an enormous surface area and a relatively low enzymatic, controlled environment for systemic absorption of medications. As a major port of entry, the lung has evolved to prevent the invasion of unwanted airborne particles from entering into the body. Airway geometry, humidity, mucociliary clearance and alveolar macrophages play a vital role in maintaining the sterility of the lung and consequently are barriers to the therapeutic effectiveness of inhaled medications. In addition, a drug's efficacy may be affected by where in the respiratory tract it is deposited, its delivered dose and the disease it may be trying to treat.
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