A Simulation Tool for Regulatory Network of Gene Expressions in the Patterning of Multicellular Organisms

Introduction Detailedkno wledge has rapidly been accumulatingo the regulatoT netwo" o geneexpressio in patterningo multicellular animals. With theexpansio o kno wledge, it is gettingmot and moP di#cultto understand and predict the wo""#E o generegulatoP netwoM#M Usageo sog simulatio to o woVB be inevitableto impro ve thinkingo researcherso generegulatoP netwo""V thoVV oo a few simulatio metho ds have been pro oo fo multicellular systems [1]. WecoAB"PTMBfi a simulatio to o fo gene regulatoT netwo) in develo""M multicellular animals. Intracellularregulatoa netwofi was co)fiPTM"B# by the etri net [2]. Wo"""A o the netwoM in individual cellso multicellular system isco oEfi)BPT by a mo deling systemfo extracellular signalings, with visual interfacewhoa o eratio and presentatio are designedto be familiar and easyto bioM)M#)PT 2 System Architecture The systemcoemP)) o two parts. One is the intracellularregulatoa netwo" mo dule (Fig. 1A). This parto the system is coVEB