Methods Comparison and Bias Estimation of Three Distinct Biochemistry Analytical Systems in One Clinical Laboratory Using Patient Samples

Significant differences for several analytes between distinct analyzers were found; for some analytes the predicted bias between dry chemical analyzer and conventional wet chemical analyzer can reach 30%, which is worthy of our concern. When one analyte was detected on more than one device, a strict method comparison study should be performed regularly. Reference intervals should be validated and transferred from the Cobas 8000 to Vitros5600 when the bias cannot be adjusted.