A Study to Ascertain Whether Hydrocortisone 17-butyrate (Locoid®) 0·1% Cream Has Any Effect on the Hypothalamic-Pituitary-Adrenal Axis in Children with Skin Diseases

A study was conducted in eight children requiring topical corticosteroid treatment for dermatological disorders. The trial was carried out with hydrocortisone 17-butyrate (Locoid) 0.1% cream. The children were treated twice daily with Locoid cream applied to areas involving at least 20% of the body surface for a period of 2 to 3 weeks. Statistical analysis did not reveal any significant changes in plasma cortisol levels after treatment compared to pre-treatment baseline levels. No side-effects were reported.