Berberine Improves Depression‐Like Behaviors and Gastrointestinal Dysfunction in 6‐Hydroxydopamine‐Induced Parkinson's Disease Rats

These findings suggested that BBR ameliorated the colonic dysfunction in 6-OHDA rats and modulated changes in enteric neurotransmitters and EGCs. Moreover, BBR regulated monoamines in the midbrain and OXA and CRF in the hypothalamus, which are associated with depression-like behaviors in 6-OHDA rats. This study provides a theoretical and experimental foundation for the potential application of BBR in treating non-motor symptoms of PD.