Advances in Microfluidics-Enabled Dimensional Design of Micro-/Nanomaterials for Biomedical Applications: A Review

Biomedical materials are of great significance for preventing and treating major diseases and protecting human health. At present, more stringent requirements have been put forward for the preparation methods and dimension control of biomedical materials based on the urgent demand for high-performance biomedical materials, especially the existence of various physiological size thresholds in vitro/in vivo. Microfluidic platforms break the limitations of traditional micro-/nanomaterial synthesis, which provide a miniaturized and highly controlled environment for size-dependent biomaterials. In this review, the basic conceptions and technical characteristics of microfluidics are first described. Then the syntheses of biomedical materials with different dimensions (0D, 1D, 2D, 3D) driven by microfluidics have been systematically summarized. Meanwhile, the applications of microfluidics-driven biomedical materials, including diagnosis, anti-inflammatory, drug delivery, antibacterial, and disease therapy, are discussed. Furthermore, the challenges and developments in the research field are further proposed. This work is expected to facilitate the convergence between the bioscience and engineering communities and continue to contribute to this emerging field.