医学
DNA测序
乳腺癌
基因组
癌症基因组测序
计算生物学
全基因组测序
癌症
肿瘤科
遗传学
DNA
内科学
基因
生物
作者
Isaac García-Murillas,Charles W. Abbott,Rosalind J. Cutts,S.M. Boyle,Jacqueline A. Pugh,Kathleen C. Keough,Bo Li,R M Pyke,Fábio C. P. Navarro,Richard Chen,Kevin Dunne,Catey Bunce,S. Johnston,Alexander Ring,Simon Russell,AA Evans,A. Skene,I. E. Smith,N.C. Turner
标识
DOI：10.1016/j.annonc.2025.01.021
摘要
A whole genome-powered MRD assay detected breast cancer relapse with a long lead time over clinical relapse, and was strongly associated with relapse-free survival. Rates of ctDNA detection at diagnosis were higher than those reported with exome-based tumour-informed assays.
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