Insights into RNA N6-methyladenosine and programmed cell death in atherosclerosis

Abstract N6-methyladenosine (m 6 A) modification stands out among various RNA modifications as the predominant form within eukaryotic cells, influencing numerous cellular processes implicated in disease development. m 6 A modification has gained increasing attention in the development of atherosclerosis and has become a research hotspot in recent years. Programmed cell death (PCD), encompassing apoptosis, autophagy, pyroptosis, ferroptosis, and necroptosis, plays a pivotal role in atherosclerosis pathogenesis. In this review, we delve into the intricate interplay between m 6 A modification and diverse PCD pathways, shedding light on their complex association during the onset and progression of atherosclerosis. Clarifying the relationship between m 6 A and PCD in atherosclerosis is of great significance to provide novel strategies for cardiovascular disease treatment.