医学
胆汁淤积
原发性胆汁性肝硬化
胃肠病学
病理生理学
原发性硬化性胆管炎
内科学
高脂血症
糖尿病
内分泌学
疾病
作者
Mariana Zapata,Hendrick Pagán-Torres,Marlyn J. Mayo
标识
DOI:10.1016/j.cld.2023.07.004
摘要
Chronic cholestasis is the hallmark clinical feature of primary biliary cholangitis. In addition to progressive liver damage, chronic cholestasis can lead to serious complications, many of which occur outside the liver. Bile acids are ligands for nuclear hormone receptors, and alterations in their concentration disrupt normal functioning of numerous different cell types. This article discusses the clinical presentation, pathophysiology, and management of pruritus (itching), fatigue, osteoporosis, hyperlipidemia, fat-soluble vitamin deficiencies, malignancies, cardiac dysfunction, bacterial cholangitis, cholemic (bile cast) nephropathy, and Sicca syndrome.
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