MoS2 embedded triangular silver nanosheets modified MOF-808 as electrochemical sensing platform for highly sensitive simultaneous detection of ACOP and 4-AP

The detection of acetaminophen (ACOP) and its toxic hydrolyzed product p-aminophenol (4-AP) is very significant for clinical diagnosis and quality control of drug formulation. In this study, a novel electrochemical sensor based on MoS2 embedding triangular Ag nanoplates (Tri-AgNPs) coated MOF-808 was developed for simultaneous and sensitive detection of ACOP and 4-AP. The morphology and structure MOF-808@MoS2/Tri-AgNPs nanocomposite were characterized by X-ray diffraction (XRD), field emission scanning electron microscopy (FESEM), energy dispersive spectroscopy (EDS), X-ray photoelectron spectroscopy (XPS) and so on. The electrochemical and electrocatalytic properties of the composite electrode were evaluated by cyclic voltammetry (CV) and differential pulse voltammetry (DPV). The experimental results demonstrated that the constructed sensor had excellent electrochemical performance for ACOP and 4-AP detection due to the synergistic interaction among MOF-808, MoS2 and Tri-AgNPs. The proposed sensor exhibited a wide linear range (1–450 μM) and low limits of detection for detection of ACOP (0.054 μM) and 4-AP (0.046 μM). At the same time, the sensor also showed outstanding repeatability, reproducibility, stability and selectivity. In addition, MOF-808@MoS2/Tri-AgNPs/GCE was also employed to determine ACOP and 4-AP in acetaminophen tablets and Yellow River water samples with satisfactory recovery rates, which indicated the feasibility of the developed electrochemical sensor in the actual sample analysis.