肿瘤微环境
声动力疗法
生化工程
工程类
活性氧
风险分析(工程)
工程伦理学
纳米技术
肿瘤细胞
癌症研究
材料科学
生物
医学
生物化学
作者
Di Yuan,Ran Deng,Lijun Zhu,Yuling Mao,Yikun Gao,Qinfu Zhao,Siling Wang
出处
期刊:Biomaterials
[Elsevier]
日期:2023-12-01
卷期号:303: 122391-122391
被引量:4
标识
DOI:10.1016/j.biomaterials.2023.122391
摘要
Reactive oxygen species (ROS) play a crucial role in regulating the metabolism of tumor growth, metastasis, death and other biological processes. ROS-based nanodynamic therapies (NDTs) are becoming attractive due to non-invasive, low side effects and tumor-specific advantages. NDTs have rapidly developed into numerous branches, such as photodynamic therapy, chemodynamic therapy, sonodynamic therapy and so on. However, the complexity of the tumor microenvironment and the limitations of existing sensitizers have greatly restricted the therapeutic effects of NDTs, which heavily rely on ROS levels. To address the limitations of NDTs, various strategies have been developed to increase ROS yield, which is an urgent aspect for the positive development of NDTs. In this review, the nanodynamic potentiation strategies in terms of unique properties and universalities of NDTs are comprehensively outlined. We mainly summarize the current dilemmas faced by each NDT and the respective solutions. Meanwhile, the NDTs universalities-based potentiation strategies and NDTs-based combined treatments are elaborated. Finally, we conclude with a discussion of the key issues and challenges faced in the development and clinical transformation of NDTs.
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