Supramolecular chitin-based hydrogels with self-adapting and fast-degradation properties for enhancing wound healing

Due to the features of high porosity, high water content, and tunable viscoelasticity, hydrogels have attracted numerous attentions in the promotion of wound closure. However, the lack of abilities to adapt the wounds of complex shapes and prevent postoperative adhesion limits their therapeutic outcomes in wound healing. To address the above challenges, the supramolecular chitin-based (SMCT) hydrogels are created via the host-guest pre-assembly strategy of β-cyclodextrin (βCD) and adamantane (Ad). The reversible host-guest crosslinks endow the SMCT hydrogels with highly dynamic networks, which can better accommodate irregularly shaped wounds compared with the covalent chitin-based hydrogels with similar mechanical properties. In addition, the SMCT hydrogels show rapid in vivo degradability (degradation time ≈ 2 days) due to the enzyme-triggered degradability of chitin, which do not need to be removed from the wounds after service and thus avoid the secondary damage to skin during dressing change. Owing to the hydrophobic cavity of βCD, the SMCT hydrogels can facilitate the load and release of curcumin with anti-inflammatory, antibacterial, and antioxidative activities, thereby significantly improving the wound healing efficiency. This work provides valuable guidance to the design of self-adaptive and fast-degradable hydrogels that hold great potential for enhancing the wound healing in skin and other tissues.