Isolating noise in water relies on materials with low acoustic impedance. However, reducing the existing materials' acoustic impedance severely compromises their stiffness and strength, resulting in a long-standing challenge of sound isolation in deep-sea environments with high ambient pressure. To overcome the mutual exclusion of low acoustic impedance and high mechanical properties, we propose a design principle including two steps that regulate the lattice orientation and incorporate a hierarchical morphology in an anisotropic metamaterial. Regulating the lattice orientation leads to low effective acoustic impedance while counterintuitively improving the initial stiffness. By learning from nature, incorporating a hierarchical morphology enables the metamaterial with an unprecedented decoupling characteristic that the mechanical strength can be enhanced independently from the acoustic impedance. A hierarchical metamaterial is constructed as a proof-of-concept demonstration and displays high sound transmission loss over 16 dB in a low and broad frequency range from 400 to 1200 Hz. Of note, the hierarchical metamaterial could maintain stable acoustic performance even under a high ambient pressure of 2 MPa. This work not only opens an alternative avenue for realizing sound isolation in deep-sea environments but also offers a design principle for metamaterials combining antagonistic functional properties.