Clinical Signature and Associated Immune Metabolism of NLRP1 in Pan-Cancer

Scattered studies have shown the connection between NLRP1 which is responsible for inflammasome formation and tumor immunity as well as tumor metabolism; however, no research has yet systematically assessed the role and function of NLRP1 on various cancer types. Thus, in this study, data were retrieved and analyzed from public databases, and further showed that NLRP1 was differentially expressed in cancers. High NLRP1 expression was associated with a favorable prognosis for lung adenocarcinoma (LUAD) and pancreatic adenocarcinoma (PAAD). NLRP1 mutation status was also found to be associated with good prognosis. Further, NLRP1 expression was negatively related to tumor stemness, whereas positively related to immune infiltration of tumors. In addition, NLRP1 was found to be significantly related to tumor metabolism. A protein-protein interaction (PPI) network analysis was conducted for NLRP1, as well as pathways and functions of NLRP1. The study aimed to explore the role and function of NLRP1 in tumors by using pan-cancer analysis, and further suggested that NLRP1 may act as a promising therapeutic target for cancer.