化学
对映选择合成
磷酸
组分(热力学)
范围(计算机科学)
基质(水族馆)
芳基
组合化学
反应条件
有机催化
构造(python库)
催化作用
有机化学
计算机科学
程序设计语言
地质学
物理
烷基
海洋学
热力学
作者
Nan-Fang Mo,Ying Zhang,Guan Zhang
出处
期刊:Organic Letters
[American Chemical Society]
日期:2022-08-26
卷期号:24 (35): 6397-6401
被引量:1
标识
DOI:10.1021/acs.orglett.2c02421
摘要
An asymmetric organocatalyzed three-component Povarov reaction to construct azaspirocycles has been developed. A chiral phosphoric acid OCF-CPA bearing o-CF3-aryl on the H8–BINOL-framework is highly efficient in the reaction. The reaction was carried out under mind conditions for synthesis of a range of azaspirocycles in high yields and high to excellent enantioselectivities, thus expending the substrate scope of the traditional Povarov reaction.
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