合成致死
基因组不稳定性
表观遗传学
生物
杀伤力
癌症
机制(生物学)
DNA修复
癌症研究
基因
计算生物学
生物信息学
遗传学
DNA损伤
DNA
哲学
认识论
作者
Ying Pang,Meng Cheng,Mu Hong Chen,Kaijun Zhao,Yuanyuan Yin,Min Liu,Jing Zhang,Chunlong Zhong
标识
DOI:10.1007/s42764-022-00080-3
摘要
Genomic instability is one of the hallmarks of tumors that contributes to tumor heterogeneity and drug resistance. Genetically targeted cancer therapy that focused on genome instability has been a direction for tumor treatment of great interest. Synthetic lethality provides a new approach for the treatment of tumor suppressor gene especially DNA damage response pathway mutation-caused cancers that were not considered as a target in traditional genetic treatment previously. Here, we summarize the systematic classification of synthetic lethality and its mechanism which was divided into gene level, including cellular signaling pathway, cell cycle regulation, metabolism, and epigenetic regulation. The goal of this review was to help deepen the understanding of the mechanism of synthetic lethality and guide the direction for exploring the new synthetic lethal relationships.
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