化学
酮
铜
基质(水族馆)
小学(天文学)
有机化学
药物化学
天文
海洋学
物理
地质学
作者
An-Jing Wang,Chun-Yan She,Yu-Die Zhang,Lingna Zhao,Wen‐Ming Shu,Weichu Yu
标识
DOI:10.1021/acs.joc.2c01814
摘要
A copper(II)-promoted denitrogenation/oxidation reaction for the preparation of primary α-ketoamides was developed using α-azido ketones as a substrate and TEMPO as an oxidant. α-Azido ketones were denitrogenated in situ to form an imino ketone intermediate, which underwent a radical addition process and radical migration to form α-ketoamides. It is worth noting that the imino ketone intermediate is the key to this reaction.
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